Structure of PDB 5hyk Chain A

Receptor sequence
>5hykA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKSLAKRIYEAYLKNFNMNKVKARVILSPFVIHDMETLCMAEKTLVAKL
VNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGV
YEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAM
KFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQ
SNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI
YRDMY
3D structure
PDB5hyk Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode.
ChainA
Resolution1.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 65W A F273 C276 Q277 S280 Y314 I354 H440 I447 K448 L456 Y464 F60 C63 Q64 S67 Y101 I141 H227 I234 K235 L243 Y251
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hyk, PDBe:5hyk, PDBj:5hyk
PDBsum5hyk
PubMed27708429
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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