Structure of PDB 5hx6 Chain A

Receptor sequence
>5hx6A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
IKMKSSDFLESAELDSGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLE
EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPL
SVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASF
KMWSKLNGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYEQ
QLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKF
RPFYLSQLE
3D structure
PDB5hx6 DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
ChainA
Resolution2.23 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D126 K128 E130 N131 D144 T159
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 65U A V31 K45 V76 L78 L90 M92 H136 D156 L157 F162 V19 K33 V64 L66 L78 M80 H124 D144 L145 F150 PDBbind-CN: -logKd/Ki=8.00,IC50=10nM
BindingDB: IC50=1.6nM,Ki=0.800000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5hx6, PDBe:5hx6, PDBj:5hx6
PDBsum5hx6
PubMed26854747
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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