Structure of PDB 5hwr Chain A

Receptor sequence
>5hwrA (length=417) Species: 246197 (Myxococcus xanthus DK 1622) [Search protein sequence]
KKRVGIEALAVAVPSRYVDIEDLARARGVDPAKYTAGLGAREMAVTDPGE
DTVALAATAAARLIRQQDVDPSRIGMLVVGTETGIDHSKPVASHVQGLLK
LPRTMRTYDTQHACYGGTAGLMAAVEWIASGAGAGKVAVVVCSDIARYGL
NTAGEPTQGGGAVALLVSEQPDLLAMDVGLNGVCSMDVYDFWRPVGRREA
LVDGHYSITCYLEALSGAYRGWREKALAAGLVRWSDALPGEQLARIAYHV
PFCKMARKAHTQLRLCDLEDAADAAASTPESREAQAKSAASYDAQVATSL
GLNSRIGNVYTASLYLALAGLLQHEAGALAGQRIGLLSYGSGCAAEFYSG
TVGEKAAERMAKADLEAVLARRERVSIEEYERLMKLPADAPEAVAPSPGA
FRLTEIRDHRRQYAEGN
3D structure
PDB5hwr Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
ChainA
Resolution1.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.3.10: hydroxymethylglutaryl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A D31 A33 K34 G38 Y149 A154 G155 T158 G205 H206 S208 I209 Y212 P252 F253 K259 D30 A32 K33 G37 Y148 A153 G154 T157 G204 H205 S207 I208 Y211 P251 F252 K258
Gene Ontology
Molecular Function
GO:0004421 hydroxymethylglutaryl-CoA synthase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006084 acetyl-CoA metabolic process
GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5hwr, PDBe:5hwr, PDBj:5hwr
PDBsum5hwr
PubMed27124816
UniProtQ1D4I1

[Back to BioLiP]