Structure of PDB 5hwp Chain A

Receptor sequence
>5hwpA (length=415) Species: 246197 (Myxococcus xanthus DK 1622) [Search protein sequence]
KRVGIEALAVAVPSRYVDIEDLARARGVDPAKYTAGLGAREMAVTDPGED
TVALAATAAARLIRQQDVDPSRIGMLVVGTETGIDHSKPVASHVQGLLKL
PRTMRTYDTQHACYGGTAGLMAAVEWIASGAGAGKVAVVVCSDIARYGLN
TAGEPTQGGGAVALLVSEQPDLLAMDVGLNGVCSMDVYDFWRPVGRREAL
VDGHYSITCYLEALSGAYRGWREKALAAGLVRWSDALPGEQLARIAYHVP
FCKMARKAHTQLRLCDLEDAADAAASTPESREAQAKSAASYDAQVATSLG
LNSRIGNVYTASLYLALAGLLQHEAGALAGQRIGLLSYGSGCAAEFYSGT
VGEKAAERMAKADLEAVLARRERVSIEEYERLMKLPADAPEAVAPSPGAF
RLTEIRDHRRQYAEG
3D structure
PDB5hwp Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.10: hydroxymethylglutaryl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A D31 K34 G38 Y149 A154 G155 G205 H206 S208 P252 F253 K259 D29 K32 G36 Y147 A152 G153 G203 H204 S206 P250 F251 K257
Gene Ontology
Molecular Function
GO:0004421 hydroxymethylglutaryl-CoA synthase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006084 acetyl-CoA metabolic process
GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5hwp, PDBe:5hwp, PDBj:5hwp
PDBsum5hwp
PubMed27124816
UniProtQ1D4I1

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