Structure of PDB 5hvy Chain A

Receptor sequence
>5hvyA (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
DKMDYDFKVKLSSERERVEDLFEYEGCKVGGHVYKAKRKDGKDDKDYALK
QIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEH
DLWHIIKFHRASVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANIL
VMGEGPERGRVKIADMGFARLPVVVTFWYRAPELLLGARHYTKAIDIWAI
GCIFAELLTSEPIFHCRKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMP
EHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRI
TSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFL
3D structure
PDB5hvy Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8.
ChainA
Resolution2.39 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D173 T196
Catalytic site (residue number reindexed from 1) D143 K145 N148 D165 T176
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 66X A A50 E66 L69 I79 Y99 A100 L148 L158 A172 D173 M174 A48 E64 L67 I77 Y97 A98 L140 L150 A164 D165 M166 MOAD: ic50=17.4nM
PDBbind-CN: -logKd/Ki=7.76,IC50=17.4nM
BindingDB: IC50=>10000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5hvy, PDBe:5hvy, PDBj:5hvy
PDBsum5hvy
PubMed27326333
UniProtP49336|CDK8_HUMAN Cyclin-dependent kinase 8 (Gene Name=CDK8)

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