Structure of PDB 5hug Chain A

Receptor sequence
>5hugA (length=388) Species: 1609053 (Influenza A virus (A/American green-winged teal/Washington/195750/2014(H5N1))) [Search protein sequence]
SVALAGNSSLCPISGWAIYSKDNGIRIGSKGDVFVIREPFISCSHLECRT
FFLTQGALLNDKHSNGTVKDRSPYRTLMSCPVGEAPSPYNSRFESVAWSA
SACHDGISWLTIGISGPDNGAVAVLKYNGIITDTIKSWRSNILRTQESEC
ACINGSCFTIMTDGPSNGQASYKIFKVEKGKVVKSVELNAPNYHYEECSC
YPDASEVMCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDG
TGSCGPVSSNGAYGVKGFSFKYGNGVWIGRTKSTSSRSGFEMIWDPNGWT
ETDSSFSVKQEIVAITDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRP
KENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK
3D structure
PDB5hug Molecular Characterizations of Surface Proteins Hemagglutinin and Neuraminidase from Recent H5Nx Avian Influenza Viruses.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 E277 R292 R371 Y406
Catalytic site (residue number reindexed from 1) D70 E197 R212 R287 Y321
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D379 N381 D387 S389 D295 N297 D303 S305
BS02 CA A D293 G297 D324 G345 Y347 D213 G217 D243 G261 Y263
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hug, PDBe:5hug, PDBj:5hug
PDBsum5hug
PubMed27053557
UniProtA0A0C5BL75

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