Structure of PDB 5hti Chain A

Receptor sequence
>5htiA (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
HIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDND
GKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG
SPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFV
HRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVAKLPVKWMALESLQ
TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPE
YCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG
3D structure
PDB5hti Crystal structure of c-Met kinase domain in complex with LXM108
ChainA
Resolution1.66 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222 A1243
Catalytic site (residue number reindexed from 1) D153 A155 R157 N158 D171 A187
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 66L A I1084 V1092 A1108 K1110 E1127 M1131 F1134 Y1159 M1160 F1200 M1211 A1221 D1222 F1223 I33 V41 A57 K59 E76 M80 F83 Y108 M109 F149 M160 A170 D171 F172
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5hti, PDBe:5hti, PDBj:5hti
PDBsum5hti
PubMed
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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