Structure of PDB 5htc Chain A

Receptor sequence
>5htcA (length=328) Species: 9606 (Homo sapiens) [Search protein sequence]
GPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDL
VNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYP
PLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLS
SLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLN
GKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFD
IYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQI
KRKIQEFHRTMLNFSSATDLLCQHSLFK
3D structure
PDB5htc Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V494 N522 H651 N654 L690 D707 L710 Q718 Y722 V24 N52 H181 N184 L220 D237 L240 Q248 Y252
BS02 66M A I490 E492 G493 F495 V498 A509 F607 G608 D611 G653 L656 I686 T689 I20 E22 G23 F25 V28 A39 F137 G138 D141 G183 L186 I216 T219 PDBbind-CN: -logKd/Ki=6.82,Kd=150nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5htc, PDBe:5htc, PDBj:5htc
PDBsum5htc
PubMed27139824
UniProtQ8TF76|HASP_HUMAN Serine/threonine-protein kinase haspin (Gene Name=HASPIN)

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