Structure of PDB 5ht2 Chain A

Receptor sequence
>5ht2A (length=255) Species: 10090 (Mus musculus) [Search protein sequence]
SKGLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVI
PPYCAYLKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKM
MRNLLCVNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDS
TTVIFAGDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNN
LRIPAAYKHRFDRIFFRAEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCT
LNVVL
3D structure
PDB5ht2 Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
ChainA
Resolution1.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A H236 S239 T240 D272 N274 R276 W307 I317 Y321 F325 H359 H122 S125 T126 D158 N160 R162 W193 I203 Y207 F211 H244
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:5ht2, PDBe:5ht2, PDBj:5ht2
PDBsum5ht2
PubMed27060144
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

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