Structure of PDB 5hrs Chain A

Receptor sequence
>5hrsA (length=139) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
CSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLA
GRWPVKTIHTDNGSNFTSNAVKAACWWAGIKQGVVESMNKELKKIIGQVR
DQAEHLKTAVQMAVFIHNKKRKGYSAGERIVDIIATDIQ
3D structure
PDB5hrs Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
ChainA
Resolution1.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 65P A A169 E170 H171 T174 M178 A103 E104 H105 T108 M112
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5hrs, PDBe:5hrs, PDBj:5hrs
PDBsum5hrs
PubMed27935939
UniProtP04585|POL_HV1H2 Gag-Pol polyprotein (Gene Name=gag-pol)

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