Structure of PDB 5hqn Chain A

Receptor sequence
>5hqnA (length=442) Species: 10090 (Mus musculus) [Search protein sequence]
DIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHEYLEGTD
PYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLGPAG
PFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGN
HESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYA
LTPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVEELQAAENRGD
KVHIIGHIPPGHCLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYD
EETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHETYI
LNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQLFQ
TFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHL
3D structure
PDB5hqn Crystal structure of mammalian acid sphingomyelinase.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.12: sphingomyelin phosphodiesterase.
3.1.4.3: phospholipase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D204 H206 D276 H457 D38 H40 D110 H291
BS02 ZN A D276 N316 H423 H455 D110 N150 H257 H289
Gene Ontology
Molecular Function
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006685 sphingomyelin catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5hqn, PDBe:5hqn, PDBj:5hqn
PDBsum5hqn
PubMed27435900
UniProtQ04519|ASM_MOUSE Sphingomyelin phosphodiesterase (Gene Name=Smpd1)

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