Structure of PDB 5hp5 Chain A

Receptor sequence
>5hp5A (length=669) Species: 9606 (Homo sapiens) [Search protein sequence]
HIEGRHMAPKRVVQLSLKMPTHAVCVVGVEAHVDIHSDVPKGANSFRVSG
SSGVEVFMVYNRTRVKEPIGKARWPLDTDADMVVSVGTASKELKDFKVRV
SYFGEQEDQALGRSVLYLTGVDISLEVDTGRTGKVKRSQGDKKTWRWGPE
GYGAILLVNCDRDNHRSAEPDLTHSWLMSLADLQDMSPMLLSCNGPDKLF
DSHKLVLNVPFSDSKRVRVFCARGGNSLSDYKQVLGPQCLSYEVERQPGE
QEIKFYVEGLTFPDADFLGLVSLSVSLVDPGTLPEVTLFTDTVGFRMAPW
IMTPNTQPPEELYVCRVMDTHGSNEKFLEDMSYLTLKANCKLTICPQVEN
RNDRWIQDEMEFGYIEAPHKSFPVVFDSPRNRGLKDFPYKRILGPDFGYV
TREIPLPGPSSLDSFGNLDVSPPVTVGGTEYPLGRILIGSSFPKSGGRQM
ARAVRNFLKAQQVQAPVELYSDWLSVGHVDEFLTFVPTSDQKGFRLLLAS
PSACLKLFQEKKEEGYGEAAQFDGLKHQAKRSINEMLADRHLQRDNLHAQ
KCIDWNRNVLKRELGLAESDIVDIPQLFFLKNFYAEAFFPDMVNMVVLGK
YLGIPKPYGPIINGRCCLEEKVQSLLEPLGLHCIFIDDYLSYHELQGEIH
CGTNVRRKPFPFKWWNMVP
3D structure
PDB5hp5 Monomeric Form of Peptidylarginine Deiminase Type I Revealed by X-ray Crystallography and Small-Angle X-ray Scattering
ChainA
Resolution3.198 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D352 H472 D474 C645
Catalytic site (residue number reindexed from 1) D358 H478 D480 C651
Enzyme Commision number 3.5.3.15: protein-arginine deiminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D155 D157 D179 K364 P389 D161 D163 D185 K370 P395
BS02 CA A N153 D155 D157 D165 D176 D179 N159 D161 D163 D171 D182 D185
BS03 CA A Q351 F409 G410 L412 Q357 F415 G416 L418
BS04 CA A D371 S372 N375 D377 S378 N381
Gene Ontology
Molecular Function
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5hp5, PDBe:5hp5, PDBj:5hp5
PDBsum5hp5
PubMed27393304
UniProtQ9ULC6|PADI1_HUMAN Protein-arginine deiminase type-1 (Gene Name=PADI1)

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