Structure of PDB 5hp2 Chain A

Receptor sequence

>5hp2A (length=396) Species: 9606 (Homo sapiens)

PSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAG
VVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLL
RFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDA
RIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDG
VLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGD
HLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTV
GDSAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITK
PNVYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT

3D structure

• PDB: 5hp2 Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
• Chain: A
• Resolution: 2.983 Å

Enzymatic activity

• Enzyme Commision number: 3.5.4.37: double-stranded RNA adenine deaminase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	V351 T375 K376 H394 E396 P450 C451 R455 H460 H471 N473 R474 S486 G487 E488	V47 T71 K72 H90 E92 P146 C147 R151 H156 H167 N169 R170 S182 G183 E184
BS02	rna	A	R348 I456 F457 H471 R474 R477 R481 G487 E488 P492 R510 G593 K594	R44 I152 F153 H167 R170 R173 R177 G183 E184 P188 R206 G289 K290
BS03	IHP	A	I397 R401 K519 R522 S531 K629 Y658 K662 Y668 K672 E689 K690	I93 R97 K215 R218 S227 K325 Y354 K358 Y364 K368 E385 K386
BS04	ZN	A	H394 C451 C516	H90 C147 C212

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004000 adenosine deaminase activity

Biological Process

• GO:0006396 RNA processing

External links

• PDB: RCSB:5hp2, PDBe:5hp2, PDBj:5hp2
• PDBsum: 5hp2
• PubMed: 27065196
• UniProt: P78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)