Structure of PDB 5hot Chain A

Receptor sequence
>5hotA (length=209) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
CSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLA
GRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFQSQGVIESMNKELKKI
IGQVRDQAEHLKTAVQMAVFIHNHKRKYSAGERIVDIIATDIQTKELQKQ
ITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAK
IIRDYGKQM
3D structure
PDB5hot Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
ChainA
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2SQ A A169 E170 H171 T174 M178 A108 E109 H110 T113 M117
BS02 2SQ A Q95 T124 T125 A128 A129 W132 Q40 T69 T70 A73 A74 W77
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:5hot, PDBe:5hot, PDBj:5hot
PDBsum5hot
PubMed27935939
UniProtQ72498

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