BioLiP

Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

BS01

BindingDB: IC50=1700nM

	Molecular Function
GO:0001758	retinal dehydrogenase activity
GO:0004032	aldose reductase (NADPH) activity
GO:0004033	aldo-keto reductase (NADPH) activity
GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0004745	all-trans-retinol dehydrogenase (NAD+) activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0032052	bile acid binding
GO:0036130	prostaglandin H2 endoperoxidase reductase activity
GO:0036131	prostaglandin D2 11-ketoreductase activity
GO:0045550	geranylgeranyl reductase activity
GO:0045703	ketoreductase activity
GO:0047017	prostaglandin F synthase activity
GO:0047020	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
GO:0047023	androsterone dehydrogenase activity
GO:0047024	5alpha-androstane-3beta,17beta-diol dehydrogenase activity
GO:0047035	testosterone dehydrogenase (NAD+) activity
GO:0047044	androstan-3-alpha,17-beta-diol dehydrogenase activity
GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity
GO:0047086	ketosteroid monooxygenase activity
GO:0047787	Delta4-3-oxosteroid 5beta-reductase activity
GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity

	Biological Process
GO:0001523	retinoid metabolic process
GO:0006629	lipid metabolic process
GO:0006693	prostaglandin metabolic process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0007584	response to nutrient
GO:0008202	steroid metabolic process
GO:0008284	positive regulation of cell population proliferation
GO:0008584	male gonad development
GO:0009267	cellular response to starvation
GO:0016488	farnesol catabolic process
GO:0019371	cyclooxygenase pathway
GO:0030216	keratinocyte differentiation
GO:0042448	progesterone metabolic process
GO:0042572	retinol metabolic process
GO:0042574	retinal metabolic process
GO:0043170	macromolecule metabolic process
GO:0044597	daunorubicin metabolic process
GO:0044598	doxorubicin metabolic process
GO:0048385	regulation of retinoic acid receptor signaling pathway
GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0061370	testosterone biosynthetic process
GO:0070293	renal absorption
GO:0071277	cellular response to calcium ion
GO:0071379	cellular response to prostaglandin stimulus
GO:0071384	cellular response to corticosteroid stimulus
GO:0071395	cellular response to jasmonic acid stimulus
GO:0071799	cellular response to prostaglandin D stimulus
GO:1900053	negative regulation of retinoic acid biosynthetic process
GO:2000224	regulation of testosterone biosynthetic process
GO:2000353	positive regulation of endothelial cell apoptotic process
GO:2000379	positive regulation of reactive oxygen species metabolic process

Biological Process

GO:0001523

retinoid metabolic process

lipid metabolic process

prostaglandin metabolic process

G protein-coupled receptor signaling pathway

response to nutrient