Structure of PDB 5hna Chain A

Receptor sequence
>5hnaA (length=352) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
LAFFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNN
RGILVILIYEYVKDINSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMR
RNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATFR
DATLKTIIGQHLDTNIFSDKYSREIDVNNINVPEQPVIDINMINFGVYKN
IVIHKTAYYSFFLPIVCGMLLAGIDNLIYKKIEDISMLMGEYFQIHDDYL
DIFDSTKTGKVSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACV
KVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEIL
FT
3D structure
PDB5hna Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
ChainA
Resolution2.693 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) K81 A121 D126 D130 R135 D198 K243 F283 D287 D288
Catalytic site (residue number reindexed from 1) K48 A86 D91 D95 R100 D163 K205 F243 D247 D248
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 63D A K81 R84 Q119 F122 L123 M129 R135 R136 Y160 Q195 K243 F283 K48 R51 Q84 F87 L88 M94 R100 R101 Y125 Q160 K205 F243 PDBbind-CN: -logKd/Ki=4.23,IC50=59uM
BS02 63D A N154 L157 N119 L122 PDBbind-CN: -logKd/Ki=4.23,IC50=59uM
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5hna, PDBe:5hna, PDBj:5hna
PDBsum5hna
PubMed27564465
UniProtA5K4U6

[Back to BioLiP]