Structure of PDB 5hld Chain A

Receptor sequence
>5hldA (length=649) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
AIVFAVLIAIYGVYLDQKIRSRIDGKVWQLPAAVYGRMVNLEPDMTISKN
EMVKLLEATQYRQVSKMTRPGEFTVQANSIEMIRRPFDFPDSKEGQVRAR
LTFDGDHLATIVNMENNRQFGFFRLDPRLITMISSPNGEQRLFVPRSGFP
DLLVDTLLATETQQLVKNLFLSKANEAYMALIMDARYSKDRILELYMNEV
YLGQSGDNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVLALERRNLVL
RLLYDMLSARPQPAFMQLVRQELQAKLGDKVKDLSGVKIFTTFDSVAQDA
AEKAAVEGIPALKKQRKLSDLETAIVVVDRFSGEVRAMVGGSEPQFAGYN
RAMQARRSIGSLAKPATYLTALSQPKIYRLNTWIADAPIALRQPNGQVWS
PQNDDRRYSESGRVMLVDALTRSMNVPTVNLGMALGLPAVTETWIKLGVP
KDQLHPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGK
VLYQSFPQAERAVPAQAAYLTLWTMQQVVQRGTGRQLGAKYPNLHLAGKT
GTTNNNVDTWFAGIDGSTVTITWVGRDNNQPTKLYGASGAMSIYQRYLAN
QTPTPLNLVPPEDIADMGVDYDGNFVCSGGMRILPVWTSDPQSLCQQSE
3D structure
PDB5hld Escherichia coli Penicillin-Binding Protein 1B: Structural Insights into Inhibition.
ChainA
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.99.28: peptidoglycan glycosyltransferase.
3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 63V A S510 D553 N574 T699 T701 T702 N703 S361 D404 N425 T550 T552 T553 N554 PDBbind-CN: -logKd/Ki=4.66,IC50=22uM
BS02 M0E A E233 Q271 K274 N275 E323 E161 Q164 K167 N168 E209 MOAD: ic50=64.3nM
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008658 penicillin binding
GO:0008955 peptidoglycan glycosyltransferase activity
Biological Process
GO:0009252 peptidoglycan biosynthetic process
GO:0046677 response to antibiotic
Cellular Component
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hld, PDBe:5hld, PDBj:5hld
PDBsum5hld
PubMed27899450
UniProtP02919|PBPB_ECOLI Penicillin-binding protein 1B (Gene Name=mrcB)

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