Structure of PDB 5hjq Chain A

Receptor sequence
>5hjqA (length=284) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
ALRSYTEIQQLLQQGKKRDVKNILRENSWPINSPIRAQLWPMLCGQHLDG
FYWEMVHQVFGTTELSEKPIMLPAFVDATHCLPYHLTSTGRAVADRIVNV
LGYDCPDITYSPVLYPITSILLHFMSEEEAYICLAGLVGSKEKVFINQTK
LQHEVTWKTVMQIAKKHTKSATSYFQRICPGLKLERIFMDWCWWILAGLP
FQHLVRIMDCYFHEGIKVLYRVALVILNLFHKECQSNNEWSPDNIKNDIG
NALIKFCKKIPVSPAKLLHAAFSIRGLSTQYISR
3D structure
PDB5hjq Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I3P A K75 R79 K277 R281 R335 G336 T339 K21 R25 K217 R221 R275 G276 T279 MOAD: Kd=19uM
PDBbind-CN: -logKd/Ki=4.72,Kd=19uM
External links
PDB RCSB:5hjq, PDBe:5hjq, PDBj:5hjq
PDBsum5hjq
PubMed27669036
UniProtQ9VIH7|SKY_DROME GTPase-activating protein skywalker (Gene Name=sky)

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