Structure of PDB 5hjm Chain A

Receptor sequence
>5hjmA (length=349) Species: 272844 (Pyrococcus abyssi GE5) [Search protein sequence]
SHHHHHHLEVLFQGPHMSGVKVRREDAKKVLELLKSVGILDGKRKAIRDE
KYVIFPVTDTNIAKSLGLEVVDVELPMRPERQIYKNLEDLLPREIFKKLG
RLDIVGDIAIVSIPDEILSEREVIVSAIRKLYPKVKVIARRGFHSGLYRI
RELEVIWGENRLHTIHKENGVLIKVDLSKVFFNPRMKGERYRIAQLVNDG
ERILVPFAGVIPYPLVIARFKNVEVYAVEINEFAVKLAEENLELNRDRLK
GKIKIIHGDVFEVLPNLPNFDRVVSPTPKGVDALSLTLSKAEKFLHYYDF
VHESEIERFRERVLEECRRQGKECRVSVRKVSDYKPHVYKVCADVEILS
3D structure
PDB5hjm Crystal structures of the bifunctional tRNA methyltransferase Trm5a
ChainA
Resolution1.762 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MTA A R133 F165 F191 E213 I214 D243 V244 P262 R149 F181 F207 E229 I230 D259 V260 P278
BS02 HSL A D266 Y281 D283 F293 D282 Y297 D299 F309
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008175 tRNA methyltransferase activity
GO:0016740 transferase activity
GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity
Biological Process
GO:0002939 tRNA N1-guanine methylation
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hjm, PDBe:5hjm, PDBj:5hjm
PDBsum5hjm
PubMed27629654
UniProtQ9V2G1|TAW22_PYRAB tRNA (guanine(37)-N1)/4-demethylwyosine(37)-methyltransferase Taw22 (Gene Name=taw22)

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