Structure of PDB 5hi2 Chain A

Receptor sequence
>5hi2A (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVG
VLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKL
IDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLSILWMA
PEVIRMNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSL
SPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL
3D structure
PDB5hi2 Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
ChainA
Resolution2.512 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D123 K125 N127 N128 D141 S145
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BAX A A481 E501 L505 L514 T529 Q530 W531 C532 F583 G593 D594 F595 A33 E48 L52 L61 T76 Q77 W78 C79 F130 G140 D141 F142 BindingDB: IC50=22nM,Kd=260nM,Ki=22nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5hi2, PDBe:5hi2, PDBj:5hi2
PDBsum5hi2
PubMed26996308
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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