Structure of PDB 5hhf Chain A

Receptor sequence

>5hhfA (length=505) Species: 746128 (Aspergillus fumigatus)

HPDISVDVLVIGAGPTGLGAAKRLNQIDGPSWMIVDSNETPGGLASTDVT
PEGFLYDVGGAVIFSHYKYFDDCLDEALPKEDDWYTHQRISYVRCQGQWV
PYPFQNNISMLPKEEQVKCIDGMIDAALEARVANTKPKTFDEWIVRMMGT
GIADLFMRPYNFKVWAVPTTKMQCAWLGERVAAPNLKAVTTNVILGKTAG
NWGPNATFRFPARGGTGGIWIAVANTLPKEKTRFGEKGKVTKVNANNKTV
TLQDGTTIGYKKLVSTMAVDFLAEAMNDQELVGLTKQLFYSSTHVIGVGV
RGSRPERIGDKCWLYFPEDNCPFYRATIFSNYSPYNQPEASAALPTMQLA
DGSRPQSTEAKEGPYWSIMLEVSESSMKPVNQETILADCIQGLVNTEMLK
PTDEIVSTYHRRFDHGYPTPTLEREGTLTQILPKLQDKDIWSRGRFGSWR
YEVGNQDHSFMLGVEAVDNIVNGAVELTLNYPDFVNGRQNTERRLVDGAQ
VFAKS

3D structure

• PDB: 5hhf In Crystallo Capture of a Covalent Intermediate in the UDP-Galactopyranose Mutase Reaction.
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 5.4.99.9: UDP-galactopyranose mutase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MRY	A	Q438 N471 E478 N482	Q436 N469 E476 N480
BS02	62F	A	G14 G16 P17 T18 D38 S39 G45 L46 G61 G62 A63 V64 F66 R182 N207 V242 M269 W315 R327 E373 Y419 G446 R447 G456 N457 Q458 S461	G12 G14 P15 T16 D36 S37 G43 L44 G59 G60 A61 V62 F64 R180 N205 V240 M267 W313 R325 E371 Y417 G444 R445 G454 N455 Q456 S459
BS03	UDP	A	Y104 F106 Q107 F158 M159 Y162 N163 W167 R182 V183 Y317 R327 Y419 Y453	Y102 F104 Q105 F156 M157 Y160 N161 W165 R180 V181 Y315 R325 Y417 Y451

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008767 UDP-galactopyranose mutase activity
• GO:0016853 isomerase activity

Biological Process

• GO:0071555 cell wall organization

External links

• PDB: RCSB:5hhf, PDBe:5hhf, PDBj:5hhf
• PDBsum: 5hhf
• PubMed: 26836146
• UniProt: Q4W1X2|GLFA_ASPFM UDP-galactopyranose mutase (Gene Name=glfA)