Structure of PDB 5hgz Chain A

Receptor sequence
>5hgzA (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEEERSSALSEVSLRLLCHDDIDTVKHLCGDWFPIEYPDSWYRDITSNK
KFFSLAATYRGAIVGMIVAEIKNRTKIHKEDGDILASNFSVDTQVAYILS
LGVVKEFRKHGIGSLLLESLKDHISTTAQDHCKAIYLHVLTTNNTAINFY
ENRDFKQHHYLPYYYSIRGVLKDGFTYVLYINGGHPPWTILDYIQHLGSA
LASLSPCSIPH
3D structure
PDB5hgz Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase
ChainA
Resolution1.383 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.259: N-terminal methionine N(alpha)-acetyltransferase NatF.
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A W33 L101 G102 V103 R108 K109 G111 G113 S114 A146 Y150 N152 R153 W33 L101 G102 V103 R108 K109 G111 G113 S114 A146 Y150 N152 R153
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0004596 peptide alpha-N-acetyltransferase activity
GO:0005515 protein binding
GO:0010485 histone H4 acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0042803 protein homodimerization activity
GO:0061733 peptide-lysine-N-acetyltransferase activity
GO:0120518 peptide-methionine-alpha-N-acetyltransferase activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006474 N-terminal protein amino acid acetylation
GO:0007059 chromosome segregation
GO:0008283 cell population proliferation
GO:0017196 N-terminal peptidyl-methionine acetylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5hgz, PDBe:5hgz, PDBj:5hgz
PDBsum5hgz
PubMed27550639
UniProtQ9H7X0|NAA60_HUMAN N-alpha-acetyltransferase 60 (Gene Name=NAA60)

[Back to BioLiP]