Structure of PDB 5hgv Chain A

Receptor sequence
>5hgvA (length=695) Species: 9606 (Homo sapiens) [Search protein sequence]
PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQ
QGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQ
INPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCL
QIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAI
AERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSNFGNHPTSHL
MQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGK
AADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALF
MDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDF
KHIYDNRIVLNGIDLKAFLDSLPDVKIVKNMPVIPMNTIAEAVIEMINRG
QIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIV
YCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNM
GLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPM
VTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKV
RGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK
3D structure
PDB5hgv How the glycosyltransferase OGT catalyzes amide bond cleavage.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S494 H496 H517 N557 H558 P559 Y632 T633 K634 Q839 V895 P897 S181 H183 H204 N244 H245 P246 Y319 T320 K321 Q506 V562 P564
BS02 UDP A Q839 K842 L866 V895 A896 K898 H901 H920 T921 T922 D925 Q506 K509 L533 V562 A563 K565 H568 H587 T588 T589 D592 BindingDB: IC50=1800nM
External links
PDB RCSB:5hgv, PDBe:5hgv, PDBj:5hgv
PDBsum5hgv
PubMed27618188
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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