Structure of PDB 5hgq Chain A

Receptor sequence

>5hgqA (length=465) Species: 7209 (Loa loa)

EYFKLRTALINERRSKGINPYPHKFHVSISLADFIAKYNSLEKDVILNDI
VQSVAGRVFSKREKLIFYDLHGEGTRLQVLANARFHSGDEAFDNLHDRIK
RGDIIGVNGYPARSKSGELSIIPYEIIQLTPCLHMLPHETRYRMRYLDLI
MNPDVKNRFVTRSRMISFLRRYLDNLGFLEVETPMMNLIAGGATAKPFIT
HHNDLDMDLYLRVAPELYLKMLVVGGIDRVYEIGRVFRNEGIDQTHNPEF
TSCEFYMAYADYEDLMKITEDMLARMVYYMHGTYKIQYHPNGIVENPVYE
VDFTPPFRKVNIYDGLQEKLGIQFPPADTLDTDEANKFFDKLAVEAPRTT
ARLLDKLIGEFLEPTFISPTFLTGHPQIMSPLAKWHRSIPGLTERFELFV
VTKEIVNAYTELNDPLTQRLRFDENYCTALEYGLPPTAGWGMGIDRLAMI
LTDSNNIKEVLFFPA

3D structure

• PDB: 5hgq Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis
• Chain: A
• Resolution: 3.283 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	LYS	A	A210 E271 N430 Y432 G479 W480	A193 E254 N407 Y409 G439 W440
BS02	KRS	A	E257 H263 N264 F267 E427 I428 V429 G483 R486	E240 H246 N247 F250 E404 I405 V406 G443 R446	PDBbind-CN: -logKd/Ki=7.34,Kd=45.2nM

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Tue Feb 18 04:14:06 2025

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '5hgq', asym_id = 'A', title = 'Protein Translation Enzyme lysyl-tRNA Synthetase... Causative Agents of Loiasis and Schistosomiasis '

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='5hgq', asym_id='A', title='Protein Translation Enzyme lysyl-tRNA Synthetase... Causative Agents of Loiasis and Schistosomiasis ')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0000166,0003676,0004812,0004824,0005524,0005737,0006418,0006430', uniprot = '', pdbid = '5hgq', asym_id = 'A'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0000166,0003676,0004812,0004824,0005524,0005737,0006418,0006430', uniprot='', pdbid='5hgq', asym_id='A')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>