Structure of PDB 5hes Chain A

Receptor sequence
>5hesA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
ASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAE
ILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMD
HIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGAS
RFHNHTGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG
LQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILE
SMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLER
3D structure
PDB5hes Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.
ChainA
Resolution2.14 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D133 K135 R137 N138 D151 T169
Catalytic site (residue number reindexed from 1) D128 K130 R132 N133 D146 T158
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 032 A G23 F27 V30 A43 I66 I80 T82 E83 Y84 A85 C150 D151 F152 G153 G18 F22 V25 A38 I61 I75 T77 E78 Y79 A80 C145 D146 F147 G148 MOAD: Kd=29nM
PDBbind-CN: -logKd/Ki=7.54,Kd=29nM
BindingDB: IC50=23nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5hes, PDBe:5hes, PDBj:5hes
PDBsum5hes
PubMed26999302
UniProtQ9NYL2|M3K20_HUMAN Mitogen-activated protein kinase kinase kinase 20 (Gene Name=MAP3K20)

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