Structure of PDB 5hcl Chain A

Receptor sequence
>5hclA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5hcl N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5Y9 A P82 F83 V87 N140 I146 P41 F42 V46 N99 I105 MOAD: ic50=6mM
PDBbind-CN: -logKd/Ki=2.22,IC50=6mM
External links
PDB RCSB:5hcl, PDBe:5hcl, PDBj:5hcl
PDBsum5hcl
PubMed28176838
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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