Structure of PDB 5hcc Chain A

Receptor sequence

>5hccA (length=982) Species: 9606 (Homo sapiens)

LQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAF
TECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVH
LVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMN
IPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIKSSKC
VRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEG
VKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLL
VGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNI
FHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFAL
RVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTL
PVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQ
STFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQ
HKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGG
FYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNF
LGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDT
QDIEAKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVE
GVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFT
VYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTIS
AETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEK
DSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTW
IEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC

3D structure

• PDB: 5hcc Structural basis for therapeutic inhibition of complement C5.
• Chain: A
• Resolution: 2.59 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CYS	A	Y700 C704	Y22 C26

Gene Ontology

Molecular Function

• GO:0004866 endopeptidase inhibitor activity

Biological Process

• GO:0006954 inflammatory response
• GO:0006956 complement activation

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space

External links

• PDB: RCSB:5hcc, PDBe:5hcc, PDBj:5hcc
• PDBsum: 5hcc
• PubMed: 27018802
• UniProt: P01031|CO5_HUMAN Complement C5 (Gene Name=C5)