Structure of PDB 5hc0 Chain A

Receptor sequence
>5hc0A (length=338) Species: 77133 (uncultured bacterium) [Search protein sequence]
KIAEDPRIDPRIKAIFSGMGGGDVESREAMLEAASSEEATAVRDGLRVFL
DACDNEEIAPSAGLKIEDYEFTSEPDGNIAKIQYIRPDSTDKLPCVYYIH
GGGMQSLSCYYGNYRAWGKIIASNGVAVAMVEFRNALVPSALPEVAPYPA
GLNDCVSGVKWVASHADELGIDASRIIIAGESGGGNLTLAAGLRLKQEGS
QDLIQGLYALCPYIAGSWPSEDSPSSTENNGILLDLHNNQGAMGYGIEAY
EMRDPLAWPGFATEEDVSGLVPTFISVNECDPLRDEGINFYRLLLRAGVS
AKCRQVMGTIHGTEIFPIACPDVSRDTAASIANFCKGG
3D structure
PDB5hc0 Structural insights of a hormone sensitive lipase homologue Est22.
ChainA
Resolution1.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G108 G109 S188 Y219 W224 D287 H317
Catalytic site (residue number reindexed from 1) G102 G103 S182 Y213 W218 D281 H311
Enzyme Commision number 3.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GOL A E80 N159 K166 R200 E204 E74 N153 K160 R194 E198
BS02 GOL A Q211 P278 F340 Q205 P272 F334
BS03 GOL A Y219 W224 L242 N244 G247 Y213 W218 L236 N238 G241
BS04 GOL A E257 R259 E251 R253
BS05 NPO A L113 E187 H317 L107 E181 H311
Gene Ontology
Molecular Function
GO:0016298 lipase activity
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:5hc0, PDBe:5hc0, PDBj:5hc0
PDBsum5hc0
PubMed27328716
UniProtH6BDX1

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