Structure of PDB 5hbj Chain A

Receptor sequence
>5hbjA (length=342) Species: 9606 (Homo sapiens) [Search protein sequence]
DKMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKD
YALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFD
YAEHDLWHIIKFHRASKAVQLPRGMVKSLLYQILDGIHYLHANWVLHRDL
KPANILVMGEGPERGRVKIADMGFLFNSPLVTFWYRAPELLLGARHYTKA
IDIWAIGCIFAELLTSEPIFHCRQSNPYHHDQLDRIFNVMGFPADKDWED
IKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMD
PIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTE
3D structure
PDB5hbj Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D173 N181 T196
Catalytic site (residue number reindexed from 1) D149 K151 N154 D171 N177 T182
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5Y8 A V27 Y32 V35 A50 K52 I79 A100 L158 A172 D173 R356 V29 Y34 V37 A52 K54 I81 A102 L156 A170 D171 R337 PDBbind-CN: -logKd/Ki=8.64,IC50=2.3nM
BindingDB: IC50=2.3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5hbj, PDBe:5hbj, PDBj:5hbj
PDBsum5hbj
PubMed26796641
UniProtP49336|CDK8_HUMAN Cyclin-dependent kinase 8 (Gene Name=CDK8)

[Back to BioLiP]