Structure of PDB 5h9b Chain A

Receptor sequence

>5h9bA (length=269) Species: 7227 (Drosophila melanogaster)

CTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQ
KLEREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVARE
FYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLA
DFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYI
LLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVN
PNKRITAAEALKHPWICQR

3D structure

• PDB: 5h9b The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase.
• Chain: A
• Resolution: 2.25 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D136 K138 N141 D157 T177
• Catalytic site (residue number reindexed from 1): D130 K132 N135 D151 T171
• Enzyme Commision number: 2.7.11.17: calcium/calmodulin-dependent protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	R53 K57 E97 F99 D136 K138 E140 L160 W171 F172 G173 F174 A175 G176 T177 P178 G179 W215	R47 K51 E91 F93 D130 K132 E134 L154 W165 F166 G167 F168 A169 G170 T171 P172 G173 W209
BS02	AN2	A	G21 K22 G23 S26 V28 A41 K43 L92 V93 E97 L143 D157	G15 K16 G17 S20 V22 A35 K37 L86 V87 E91 L137 D151
BS03	MG	A	N141 D157	N135 D151

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:5h9b, PDBe:5h9b, PDBj:5h9b
• PDBsum: 5h9b
• PubMed: 30381148
• UniProt: Q00168|KCC2A_DROME Calcium/calmodulin-dependent protein kinase type II alpha chain (Gene Name=CaMKII)