Structure of PDB 5h8w Chain A

Receptor sequence
>5h8wA (length=596) Species: 2303 (Thermoplasma acidophilum) [Search protein sequence]
QKSYGVALESPTGSGKTIMALKSALQYSSERKLKVLYLVRTNSQEEQVIK
ELRSLSSTMKIRAIPMQGRVNMCILYRMVDDLHEINAESLAKFCNMKKRE
VMAGNEAACPYFNFKIRSDETKRFLFDELPTAEEFYDYGERNNVCPYESM
KAALPDADIVIAPYAYFLNRSVAEKFLSHWGVSRNQIVIILDEAHNLPDI
GRSIGSFRISVESLNRADREAQAYGDPELSQKIHVSDLIEMIRSALQSMV
SERCGKGDVRIRFQEFMEYMRIMNKRSEREIRSLLNALYLFGEYVENEKE
KVGKVPFSYASSVASRIIAFSDQDEEKYAAILSPEDGGYMQAAALDPSGI
LEVLKESKTIHMSGTLDPFDFYSDITGFEIPFKKIGEIFPPENRYIAYYD
GVSSKYDTLDEKELDRMATVIEDIILKVKKNTIVYFPSYSLMDRVENRVS
FEHMKEYRGIDQKELYSMLKKFRRDHGTIFAVSGGRLSEGINFPGNELEM
IILAGLPFPRPDAINRSLFDYYCRKYGKGWEYSVVYPTAIKIRQEIGRLI
RSAEDTGAAVILDKRAGQFRKFIPDMKKTSDPASDIYNFFISAQAR
3D structure
PDB5h8w Mechanism of DNA loading by the DNA repair helicase XPD.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E354 K424 Y425 S457 Y458 F527 P528 R529 P530 N534 F538 W549 V553 R584 E335 K405 Y406 S438 Y439 F508 P509 R510 P511 N515 F519 W530 V534 R565
BS02 SF4 A R88 C92 L94 C113 C128 C164 R69 C73 L75 C94 C109 C145
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006281 DNA repair
GO:0032508 DNA duplex unwinding

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Molecular Function
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Biological Process
External links
PDB RCSB:5h8w, PDBe:5h8w, PDBj:5h8w
PDBsum5h8w
PubMed26896802
UniProtQ9HM14|XPD_THEAC ATP-dependent DNA helicase XPD (Gene Name=Ta0057)

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