Structure of PDB 5h8t Chain A

Receptor sequence
>5h8tA (length=139) Species: 9606 (Homo sapiens) [Search protein sequence]
VDFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMII
RTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLQCVQKGEK
EGRGWTQWIEGDELHLEMRVEGVVCKQVFKKVQHHHHHH
3D structure
PDB5h8t Ligand Binding Induces Conformational Changes in Human Cellular Retinol-binding Protein 1 (CRBP1) Revealed by Atomic Resolution Crystal Structures.
ChainA
Resolution1.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RTL A K40 G76 I77 W106 Q108 M119 K39 G75 I76 W105 Q107 M118 MOAD: Kd=18.5nM
Gene Ontology
Molecular Function
GO:0005501 retinoid binding
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0016918 retinal binding
GO:0019841 retinol binding
GO:1904768 all-trans-retinol binding
Biological Process
GO:0002138 retinoic acid biosynthetic process
GO:0006776 vitamin A metabolic process
GO:0015908 fatty acid transport
GO:0055088 lipid homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:5h8t, PDBe:5h8t, PDBj:5h8t
PDBsum5h8t
PubMed26900151
UniProtP09455|RET1_HUMAN Retinol-binding protein 1 (Gene Name=RBP1)

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