Structure of PDB 5h8q Chain A

Receptor sequence
>5h8qA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
NHLSIVTLEEAPFVIVEDIDPETCVRNTVPCRKFVKINNSTNEGMNVKKC
CKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRA
VMAVGSLTINEERSEVVDFSVPFVETGISVMVSRGTQVTGLSDKKFQRPH
DYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGK
LDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQ
IDLALLQFVGDGEMEELETLWLTGIC
3D structure
PDB5h8q Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A H87 T115 R120 G171 S172 T173 Y213 D214 H80 T108 R113 G164 S165 T166 Y206 D207
BS02 5YE A P129 V131 E132 T241 T242 G243 V266 P122 V124 E125 T234 T235 G236 V259
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5h8q, PDBe:5h8q, PDBj:5h8q
PDBsum5h8q
PubMed26875626
UniProtQ12879|NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (Gene Name=GRIN2A)

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