Structure of PDB 5h8h Chain A

Receptor sequence
>5h8hA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
DNHLSIVTLEEAPFVIVEDIDPETCVRNTVPCRKFVKINNSTNEGMNVKK
CCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQR
AVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRGTQVTGLSDKKFQRP
HDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTG
KLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKR
QIDLALLQFVGDGEMEELETLWLTGIC
3D structure
PDB5h8h Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
ChainA
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A H87 T115 R120 G171 S172 T173 Y213 D214 H81 T109 R114 G165 S166 T167 Y207 D208
BS02 5YC A P129 V131 E132 T242 G243 P123 V125 E126 T236 G237 BindingDB: EC50=1900nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5h8h, PDBe:5h8h, PDBj:5h8h
PDBsum5h8h
PubMed26875626
UniProtQ12879|NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (Gene Name=GRIN2A)

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