Structure of PDB 5h8c Chain A

Receptor sequence
>5h8cA (length=335) Species: 2285 (Sulfolobus acidocaldarius) [Search protein sequence]
QEKLKDKVIEGLRNNFLVALNAPTGSGKTLFSLLVSLEVKPKVLFVVRTH
NEFYPIYRDLTKIREKRNITFSFLVGKPSSCLYAEKGAESEDIPCKYCEL
KGSIVEVKTDDSPLSLVKKLKKDGLQDKFCPYYSLLNSLYKADVIALTYP
YFFIDRYREFIDIDLREYMIVIDEAHNLDKVNELEERSLSEITIQMAIKQ
SKSEESRRILSKLLNQLREVVLPDEKYIKVENVPKLSKEELEILADDYED
IRKDSLKQGKVNKIHIGSILRFFSLLFIPFSYSKRLVIKNPEISYYLNLL
NDNELSIILMSGTLPPREYMEKVWGIKRNMLYLDV
3D structure
PDB5h8c Mechanism of DNA loading by the DNA repair helicase XPD.
ChainA
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 A C88 Y90 I100 C102 C105 K108 C137 C81 Y83 I93 C95 C98 K101 C130
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0043139 5'-3' DNA helicase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0140097 catalytic activity, acting on DNA
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006281 DNA repair
GO:0032508 DNA duplex unwinding
GO:0071103 DNA conformation change

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5h8c, PDBe:5h8c, PDBj:5h8c
PDBsum5h8c
PubMed26896802
UniProtQ4JC68|XPD_SULAC ATP-dependent DNA helicase XPD (Gene Name=xpd)

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