Structure of PDB 5h84 Chain A

Receptor sequence
>5h84A (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
SGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFD
PKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLM
NHLKEYHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDY
EGATLMECELNPRI
3D structure
PDB5h84 Structural basis for acyl-group discrimination by human Gcn5L2.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F74 F79 E81 I82 V83 C85 L117 I148 Y151
Catalytic site (residue number reindexed from 1) F73 F78 E80 I81 V82 C84 L116 I147 Y150
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1VU A Q36 L37 C85 V87 Q92 V93 G95 G97 T98 T118 Y119 A124 G126 Y127 F128 K130 Q35 L36 C84 V86 Q91 V92 G94 G96 T97 T117 Y118 A123 G125 Y126 F127 K129
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:5h84, PDBe:5h84, PDBj:5h84
PDBsum5h84
PubMed27377381
UniProtQ92830|KAT2A_HUMAN Histone acetyltransferase KAT2A (Gene Name=KAT2A)

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