Structure of PDB 5h6v Chain A

Receptor sequence
>5h6vA (length=38) Species: 64320 (Zika virus) [Search protein sequence]
DMYIERAGDITWEKDAEVTGNSPRLDVALDESGDFSLV
3D structure
PDB5h6v Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors
ChainA
Resolution2.422 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7HS A G82 D83 G33 D34 PDBbind-CN: -logKd/Ki=6.68,IC50=208nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Cellular Component
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5h6v, PDBe:5h6v, PDBj:5h6v
PDBsum5h6v
PubMed28689970
UniProtH8XX12

[Back to BioLiP]