Structure of PDB 5h6o Chain A

Receptor sequence
>5h6oA (length=281) Species: 666 (Vibrio cholerae) [Search protein sequence]
TPIRIATRQSPLALWQANYVKDALMAAHPGLQVELVTMVFVKELEIAMLE
GRADLAVHSMKDVPVDFPDGLGLVTICEREDPRDAFVSNTYAKIEDLPSG
AIVGTCSLRRQCQLKAARPDLVIKELRGNVGTRLSKLDAGEYDAIILAAA
GLKRLELESRIRSFIEPEQSLPAVGQGAVGIECRVNDQRVRALLAPLNHA
DTADRVRCERAMNLTLQGGCQVPIGSYALLEGDTIWLRALVGEPDGSQIV
RGEIRGPRTQAEQLGITLAEQLLSQGAKEIL
3D structure
PDB5h6o Porphobilinogen deaminase from Vibrio Cholerae
ChainA
Resolution2.702 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K89 D90 R137 R138 R155 R161 C248
Catalytic site (residue number reindexed from 1) K61 D62 R109 R110 R127 R133 C220
Enzyme Commision number 2.5.1.61: hydroxymethylbilane synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DPM A S87 K89 D90 C134 S135 R137 R138 R161 A176 Q204 G205 C248 S59 K61 D62 C106 S107 R109 R110 R133 A148 Q176 G177 C220
BS02 MG A L21 V158 L12 V130
Gene Ontology
Molecular Function
GO:0004418 hydroxymethylbilane synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0018160 peptidyl-pyrromethane cofactor linkage
GO:0033014 tetrapyrrole biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:5h6o, PDBe:5h6o, PDBj:5h6o
PDBsum5h6o
PubMed
UniProtQ9KVM1|HEM3_VIBCH Porphobilinogen deaminase (Gene Name=hemC)

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