Structure of PDB 5h5s Chain A

Receptor sequence
>5h5sA (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
DWRAARSMHEFSAKDIDGHMVNLDKYRGFVSIVTNVASQDGKTEVNYTQL
VDLHARYAERGLRILAFPSNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKI
EVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGVVVKRYGPM
EEPLVIEKDLPHYF
3D structure
PDB5h5s Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D73 Q108 W163
Catalytic site (residue number reindexed from 1) D40 Q75 W130
Enzyme Commision number 1.11.1.12: phospholipid-hydroperoxide glutathione peroxidase.
1.11.1.9: glutathione peroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G155 I156 L157 K162 W163 R179 P182 M183 G122 I123 L124 K129 W130 R146 P149 M150
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
Biological Process
GO:0006979 response to oxidative stress

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Molecular Function
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Biological Process
External links
PDB RCSB:5h5s, PDBe:5h5s, PDBj:5h5s
PDBsum5h5s
PubMed27836545
UniProtP36969|GPX4_HUMAN Phospholipid hydroperoxide glutathione peroxidase GPX4 (Gene Name=GPX4)

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