Structure of PDB 5h43 Chain A

Receptor sequence

>5h43A (length=428) Species: 9606 (Homo sapiens) [Search protein sequence]

NQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAG
LIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFIS
LLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMS
SLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLA
DTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGN
IVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQ
IQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHC
GIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGG
LDKIEALQNHENESVYKASLSLIEKYFS

3D structure

PDB

5h43 Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin alpha 1

Chain

Resolution

2.3 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	R315 V321 T322 D325 T328 K353 E354 W357 N361 A364 G365 E396 W399 N403 S406	R246 V252 T253 D256 T259 K284 E285 W288 N292 A295 G296 E327 W330 N334 S337
BS02	peptide	A	S105 W142 N146 S149 G150 T155 W184 N188 G191 D192 W231 R238 N239 P265 W273 P308 T311	S36 W73 N77 S80 G81 T86 W115 N119 G122 D123 W162 R169 N170 P196 W204 P239 T242

External links

PDB	RCSB:5h43, PDBe:5h43, PDBj:5h43
PDBsum	5h43
PubMed	28991411
UniProt	P52292\|IMA1_HUMAN Importin subunit alpha-1 (Gene Name=KPNA2)

[Back to BioLiP]