Structure of PDB 5h3q Chain A

Receptor sequence
>5h3qA (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
SGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNKM
LVAVKALKEARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMR
HGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG
LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRW
MPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQG
RELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLD
VL
3D structure
PDB5h3q The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D650 A652 R654 N655 D668 S677 L689
Catalytic site (residue number reindexed from 1) D157 A159 R161 N162 D175 S184 L196
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7HF A L486 G488 H489 I490 F521 K544 E560 V573 M587 F589 L641 V647 H648 G667 D668 F669 G670 L795 L3 G5 H6 I7 F38 K55 E67 V80 M94 F96 L148 V154 H155 G174 D175 F176 G177 L302 MOAD: ic50=6nM
PDBbind-CN: -logKd/Ki=8.22,IC50=6nM
BindingDB: IC50=6.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5h3q, PDBe:5h3q, PDBj:5h3q
PDBsum5h3q
PubMed28159414
UniProtP04629|NTRK1_HUMAN High affinity nerve growth factor receptor (Gene Name=NTRK1)

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