Structure of PDB 5h21 Chain A

Receptor sequence
>5h21A (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]
MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPT
3D structure
PDB5h21 Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay.
ChainA
Resolution1.591 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RMR A F83 L92 Y97 Y139 N140 I146 F41 L50 Y55 Y97 N98 I104 PDBbind-CN: -logKd/Ki=5.19,IC50=6.4uM
External links
PDB RCSB:5h21, PDBe:5h21, PDBj:5h21
PDBsum5h21
PubMed30108844
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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