Structure of PDB 5h1v Chain A

Receptor sequence
>5h1vA (length=169) Species: 9606 (Homo sapiens) [Search protein sequence]
NEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLS
KPEVEYKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDY
YKIIKNPMDLSTIKKRLQESMYSKPEDFVADFRLIFQNCAEFNEPDSEVA
NAGIKLENYFEELLKNLYP
3D structure
PDB5h1v The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network
ChainA
Resolution2.002 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C829 C832 H849 C852 C5 C8 H25 C28
BS02 ZN A C841 C844 C867 C870 C17 C20 C43 C46
BS03 7FU A A923 F924 V928 Y935 C976 N980 A88 F89 V93 Y100 C139 N143 MOAD: Kd=34uM
PDBbind-CN: -logKd/Ki=4.00,Kd=0.1mM
External links
PDB RCSB:5h1v, PDBe:5h1v, PDBj:5h1v
PDBsum5h1v
PubMed28207202
UniProtO15164|TIF1A_HUMAN Transcription intermediary factor 1-alpha (Gene Name=TRIM24)

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