Structure of PDB 5h1t Chain A

Receptor sequence
>5h1tA (length=172) Species: 9606 (Homo sapiens) [Search protein sequence]
NEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLS
KPEVEYDKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPD
YYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDS
EVANAGIKLENYFEELLKNLYP
3D structure
PDB5h1t The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network
ChainA
Resolution1.951 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C829 C832 H849 C852 C5 C8 H25 C28
BS02 ZN A C841 C844 C867 C870 C17 C20 C43 C46
BS03 7FF A A923 F924 F979 N980 A89 F90 F145 N146 MOAD: Kd=0.16mM
PDBbind-CN: -logKd/Ki=3.80,Kd=0.16mM
External links
PDB RCSB:5h1t, PDBe:5h1t, PDBj:5h1t
PDBsum5h1t
PubMed28207202
UniProtO15164|TIF1A_HUMAN Transcription intermediary factor 1-alpha (Gene Name=TRIM24)

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