Structure of PDB 5h17 Chain A

Receptor sequence
>5h17A (length=357) Species: 9606 (Homo sapiens) [Search protein sequence]
KCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYEC
HSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIIN
PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV
AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE
SYDYPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKP
GKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQV
GKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDAS
IWRWDRL
3D structure
PDB5h17 Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W103 H104 S105 E107 Y154 S159 H160 R201 L246 L247 L315 G316 D317 L318 W373 Q374 E392 E394 R420 W27 H28 S29 E31 Y78 S83 H84 R125 L170 L171 L232 G233 D234 L235 W290 Q291 E309 E311 R337
BS02 LQE A F97 Y148 N194 D310 Y365 R367 R414 F21 Y72 N118 D227 Y282 R284 R331 MOAD: ic50=0.89uM
PDBbind-CN: -logKd/Ki=6.05,IC50=0.89uM
BindingDB: IC50=2500nM
External links
PDB RCSB:5h17, PDBe:5h17, PDBj:5h17
PDBsum5h17
PubMed28072869
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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