Structure of PDB 5h13 Chain A

Receptor sequence
>5h13A (length=361) Species: 9606 (Homo sapiens) [Search protein sequence]
GILENLYFQGKKCKYSFKCVNSLKEDHNQPLFGVQFNWHLVFATVGSNRV
TLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGI
IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ
TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMM
NAIKESYDYFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIV
CWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLAL
GNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVC
DDASIWRWDRL
3D structure
PDB5h13 Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LQA A P95 F97 N146 Y148 N194 Y365 R367 R414 P30 F32 N75 Y77 N123 Y286 R288 R335 MOAD: ic50=11.58uM
PDBbind-CN: -logKd/Ki=4.94,IC50=11.58uM
External links
PDB RCSB:5h13, PDBe:5h13, PDBj:5h13
PDBsum5h13
PubMed28072869
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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