Structure of PDB 5h08 Chain A

Receptor sequence
>5h08A (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
GPAIPIKHFPKHVADLHASSGFTEEFEEVQSCTVDLGITADSSNHPDNKH
KNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQG
PLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNF
LVTQKSVQVLAYYTVRNFTLRNTKIRVVTQYHYTQWPDMGVPEYSLPVLT
FVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFG
FLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS
3D structure
PDB5h08 Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells
ChainA
Resolution2.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1831 W1899 D1901 H1932 C1933 R1939 T1940 Q1977
Catalytic site (residue number reindexed from 1) E129 W186 D188 H219 C220 R226 T227 Q264
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7WL A Y1896 Q1898 W1899 P1905 R1939 Y1943 Q1977 E1980 Q1981 F1984 Y183 Q185 W186 P192 R226 Y230 Q264 E267 Q268 F271 PDBbind-CN: -logKd/Ki=5.96,Kd=1.1uM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5h08, PDBe:5h08, PDBj:5h08
PDBsum5h08
PubMed28717188
UniProtP23471|PTPRZ_HUMAN Receptor-type tyrosine-protein phosphatase zeta (Gene Name=PTPRZ1)

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