Structure of PDB 5gxu Chain A

Receptor sequence

>5gxuA (length=552) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]

KKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYE
EKLKKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVF
GLGNRQYEHFNKVAKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWRE
ALWPELDTILYTVFDAQHPYKANVAVKRELHTPESDRSCIHLEFDIAGSG
LTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLPFPPCNLRTALTR
YACLLSSPKKSALVALAAHASDPTEAERLKHLASPAGKDEYSKWVVESQR
SLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVTCA
LVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDS
KVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFI
YEEELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGA
YLYVCGDAKGMARDVHRSLHTIAQEQGSMDSTKAEGFVKNLQTSGRYLRD
VW

3D structure

PDB

5gxu Structure of the Arabidopsis thaliana NADPH-cytochrome P450 reductase 2 (ATR2) provides insight into its function

Chain

Resolution

2.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Y491 S492 C664 D709 W711
Catalytic site (residue number reindexed from 1)	Y332 S333 C505 D550 W552
Enzyme Commision number	1.6.2.4: NADPH--hemoprotein reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FMN	A	T111 Q112 T113 T115 A116 T167 Y168 G169 G205 N206 Y209 H211 F212 D239	T9 Q10 T11 T13 A14 T65 Y66 G67 G103 N104 Y107 H109 F110 D137
BS02	FAD	A	S416 Q458 R489 F490 Y491 S492 T507 C508 V511 M515 H521 G523 V524 C525 S526 T570 W711	S257 Q299 R330 F331 Y332 S333 T348 C349 V352 M356 H362 G364 V365 C366 S367 T411 W552

Gene Ontology

	Molecular Function
GO:0003958	NADPH-hemoprotein reductase activity
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

	Biological Process
GO:0009698	phenylpropanoid metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0009507	chloroplast
GO:0016020	membrane

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5gxu, PDBe:5gxu, PDBj:5gxu
PDBsum	5gxu
PubMed	28103421
UniProt	Q9SUM3\|NCPR2_ARATH NADPH--cytochrome P450 reductase 2 (Gene Name=ATR2)

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