Structure of PDB 5gwz Chain A

Receptor sequence
>5gwzA (length=299) Species: 229032 (Porcine epidemic diarrhea virus CV777) [Search protein sequence]
GLRKMAQPSGVVEKCIVRVCYGNMALNGLWLGDIVMCPRHVIASSTTSTI
DYDYALSVLRLHNFSISSGNVFLGVVSATMRGALLQIKVNQNNVHTPKYT
YRTVRPGESFNILACYDGAAAGVYGVNMRSNYTIRGSFINGACGSPGYNI
NNGTVEFCYLHQLELGSGCHVGSDLDGVMYGGYEDQPTLQVEGASSLFTE
NVLAFLYAALINGSTWWLSSSRIAVDRFNEWAVHNGMTTVGNTDCFSILA
AKTGVDVQRLLASIQSLHKNFGGKQILGHTSLTDEFTTGEVVRQMYGVN
3D structure
PDB5gwz Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus
ChainA
Resolution2.444 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H41 G142 C144
Catalytic site (residue number reindexed from 1) H40 G141 C143
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N141 G142 C144 H162 Q163 L164 E165 P188 T189 L190 N140 G141 C143 H161 Q162 L163 E164 P187 T188 L189
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5gwz, PDBe:5gwz, PDBj:5gwz
PDBsum5gwz
PubMed28287727
UniProtP0C6V6|R1A_PEDV7 Replicase polyprotein 1a (Gene Name=1a)

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