Structure of PDB 5gwy Chain A

Receptor sequence
>5gwyA (length=298) Species: 277944 (Human coronavirus NL63) [Search protein sequence]
LKKMAQPSGCVERCVVRVCYGSTVLNGVWLGDTVTCPRHVIAPSTTVLID
YDHAYSTMRLHNFSVSHNGVFLGVVGVTMHGSVLRIKVSQSNVHTPKHVF
KTLKPGDSFNILACYEGIASGVFGVNLRTNFTIKGSFINGACGSPGYNVR
NDGTVEFCYLHQIELGSGAHVGSDFTGSVYGNFDDQPSLQVESANLMLSD
NVVAFLYAALLNGCRWWLCSTRVNVDGFNEWAMANGYTSVSSVECYSILA
AKTGVSVEQLLASIQHLHEGFGGKNILGYSSLCDEFTLAEVVKQMYGV
3D structure
PDB5gwy Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design.
ChainA
Resolution2.852 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H41 G142 C144
Catalytic site (residue number reindexed from 1) H39 G140 C142
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H41 F139 C144 H163 Q164 I165 E166 D187 P189 S190 L191 H39 F137 C142 H161 Q162 I163 E164 D185 P187 S188 L189
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5gwy, PDBe:5gwy, PDBj:5gwy
PDBsum5gwy
PubMed26948040
UniProtP0C6U6|R1A_CVHNL Replicase polyprotein 1a (Gene Name=1a)

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